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Browse result page of B3Pdb
The total number entries retrieved from this search are
36
, scroll left/right for detailed information.
B3pdbID
PEPTIDE NAME
PEPTIDE SEQUENCE (1-letter)
PEPTIDE SEQUENCE (3-letter)
N-TERMINAL MODIFICATION
C-TERMINAL MODIFICATION
CHEMICAL MODIFICATION
PEPTIDE LENGTH
PEPTIDE CONFORMATION
PEPTIDE NATURE
SOURCE/ORIGIN OF PEPTIDE
SMILES
CELL LINE
In vitro
CONCENTRATION
In vitro
METHOD
In vitro
RESULT
ANIMAL MODEL
In vivo
CONCENTRATION
In vivo
MODE OF DELIVERY
In vivo
METHOD
In vivo
RESULT
ACTION
TRANSPORT TYPE
SUBCELLULAR LOCALISATION
COMBINATION
PHYSICAL CONDITION
RESPONSE
RESULT
LABEL
PMID
b3pdb_0008
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA N315
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Alone
NA
MIC
6.3 ± 1.3 micromolar
NA
30824786
b3pdb_0009
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
N-terminal Fmoc group was removed and the propiola
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA N315
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Alone
NA
MIC
1.6 ± 0.9micromolar
NA
30824786
b3pdb_0010
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
N-terminal Fmoc group was removed and the propiola
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA N315
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Alone
NA
MIC
1.6 ± 0.8 micromolar
NA
30824786
b3pdb_0011
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA N315
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows the resistance
NA
NA
Alone
NA
MIC
12.5 ± 3.2 micromolar
NA
30824786
b3pdb_0012
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA N315
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Alone
NA
MIC
6.3 ± 1.6 micromolar
NA
30824786
b3pdb_0013
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
6-carboxyfluorescein (Fl) was coupled to the N-ter
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA N315
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Alone
NA
MIC
6.3 ± 1.6 micromolar
NA
30824786
b3pdb_0014
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA 12673
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
6.3 ± 1.6 micromolar
NA
30824786
b3pdb_0015
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
N-terminal Fmoc group was removed and the propiola
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA 12673
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
1.6 ± 0.9 micromolar
NA
30824786
b3pdb_0016
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
N-terminal Fmoc group was removed and the propiola
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA 12673
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
1.6 ± 0.7 micromolar
NA
30824786
b3pdb_0017
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA 12673
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows high sensitivity
NA
NA
Combined with Vanomycin
NA
MIC
0.8 ± 0.4 micromolar
NA
30824786
b3pdb_0018
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA 12673
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows high sensitivity
NA
NA
Combined with Vanomycin
NA
MIC
0.8 ± 0.3 micromolar
NA
30824786
b3pdb_0019
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
6-carboxyfluorescein (Fl) was coupled to the N-ter
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA 12673
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows high sensitivity
NA
NA
Combined with Vanomycin
NA
MIC
0.8 ± 0.3 micromolar
NA
30824786
b3pdb_0020
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA hetero-VISA 6347b
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows high sensitivity
NA
NA
Combined with Vanomycin
NA
MIC
12.5 ± 3.2 micromolar
NA
30824786
b3pdb_0021
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
N-terminal Fmoc group was removed and the propiola
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA hetero-VISA 6347b
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
1.6 ± 0.3 micromolar
NA
30824786
b3pdb_0022
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
N-terminal Fmoc group was removed and the propiola
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA hetero-VISA 6347b
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
3.1 ± 0.8 micromolar
NA
30824786
b3pdb_0023
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA hetero-VISA 6347b
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
1.6 ± 0.4 micromolar
NA
30824786
b3pdb_0024
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA hetero-VISA 6347b
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
3.1 ± 0.8 micromolar
NA
30824786
b3pdb_0025
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
6-carboxyfluorescein (Fl) was coupled to the N-ter
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
S. aureus MRSA hetero-VISA 6347b
100000 CFU/mL
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
3.1 ± 0.8 micromolar
NA
30824786
b3pdb_0026
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Enterococcus faecium 3934825
NA
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
12.5 ± 3.4 micromolar
NA
30824786
b3pdb_0027
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
N-terminal Fmoc group was removed and the propiola
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Enterococcus faecium 3934825
NA
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows the resistance
NA
NA
Combined with Vanomycin
NA
MIC
50.0 ± 10.2 micromolar
NA
30824786
b3pdb_0028
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
N-terminal Fmoc group was removed and the propiola
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Enterococcus faecium 3934825
NA
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows the resistance
NA
NA
Combined with Vanomycin
NA
MIC
25.0 ± 5.1 micromolar
NA
30824786
b3pdb_0029
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Enterococcus faecium 3934825
NA
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
12.5 ± 3.2 micromolar
NA
30824786
b3pdb_0030
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Enterococcus faecium 3934825
NA
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
6.3 ± 1.7 micromolar
NA
30824786
b3pdb_0031
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
6-carboxyfluorescein (Fl) was coupled to the N-ter
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Enterococcus faecium 3934825
NA
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
6.3 ± 1.7 micromolar
NA
30824786
b3pdb_0032
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Enterococcus faecalis 3937158
NA
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
12.5 ± 2.2 micromolar
NA
30824786
b3pdb_0033
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
N-terminal Fmoc group was removed and the propiola
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Enterococcus faecalis 3937158
NA
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows intermediate susceptibility.
NA
NA
Combined with Vanomycin
NA
MIC
6.3 ± 1.6 micromolar
NA
30824786
b3pdb_0034
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
N-terminal Fmoc group was removed and the propiola
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Enterococcus faecalis 3937158
NA
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows the resistance
NA
NA
Combined with Vanomycin
NA
MIC
25.0 ± 6.5 micromolar
NA
30824786
b3pdb_0035
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Enterococcus faecalis 3937158
NA
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows the resistance
NA
NA
Combined with Vanomycin
NA
MIC
25.0 ± 5.1 micromolar
NA
30824786
b3pdb_0036
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
NA
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Enterococcus faecalis 3937158
NA
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows the resistance
NA
NA
Combined with Vanomycin
NA
MIC
25.0 ± 6.9 micromolar
NA
30824786
b3pdb_0037
Transportan 10
AGYLLGKINLKALAALAKKIL
AlaGlyTyrLeuLeuGlyLysIleAsnLeuLysAlaLeuAlaAlaLeuAlaLysLysIleLeu
6-carboxyfluorescein (Fl) was coupled to the N-ter
Amide group is attached
NA
21
Linear
Cationic
Chemically synthesized
N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
Enterococcus faecalis 3937158
NA
NA
NA
BALB/c mice
60 mg/kg
Intravenous
Fluorescence microscopy assay
It crosses the BBB.
It shows the resistance
NA
NA
Combined with Vanomycin
NA
MIC
25.0 ± 6.9 micromolar
NA
30824786
b3pdb_0136
G23
HLNILSTLWKYR
HisLeuAsnIleLeuSerThrLeuTrpLysTyrArg
NA
NA
NA
12
Linear
NA
Phage display of prion proteins
NA
NA
NA
NA
NA
BALB/c mice
NA
Intravenous
Radioimaging
0.052 + 0.019 of fluoroscent measured in btain tissue after 4 hours
NA
Transcytosis as well as BBB penetration
NA
NA
NA
NA
NA
NA
22536790
b3pdb_0137
G23
HLNILSTLWKYR
HisLeuAsnIleLeuSerThrLeuTrpLysTyrArg
NA
NA
NA
12
Linear
NA
Phage display of prion proteins
NA
NA
NA
NA
NA
BALB/c mice
NA
Intravenous
Radioimaging
0.047 + 0.031 of fluoroscent measured in btain tissue after 24 hours
NA
Transcytosis as well as BBB penetration
NA
NA
NA
NA
NA
NA
22536790
b3pdb_0138
Scr-G23
KISHLLNYRTWL
LysIleSerHisLeuLeuAsnTyrArgThrTrpLeu
NA
NA
NA
12
Linear
NA
Phage display of prion proteins
NA
NA
NA
NA
NA
BALB/c mice
NA
Intravenous
Radioimaging
0.013 + 0.006 of fluoroscent measured in btain tissue after 4 hours
NA
Transcytosis as well as BBB penetration
NA
NA
NA
NA
NA
NA
22536790
b3pdb_0139
Scr-G23
KISHLLNYRTWL
LysIleSerHisLeuLeuAsnTyrArgThrTrpLeu
NA
NA
NA
12
Linear
NA
Phage display of prion proteins
NA
NA
NA
NA
NA
BALB/c mice
NA
Intravenous
Radioimaging
0.008 + 0.002 of fluoroscent measured in btain tissue after 24 hours
NA
Transcytosis as well as BBB penetration
NA
NA
NA
NA
NA
NA
22536790
b3pdb_0232
NA
RGD
ArgGlyAsp
NA
NA
NA
3
Linear
Cationic
Chemically synthesized
NA
NA
NA
NA
NA
BALB/c mice xenograft for U87MG glioma cells
5mg/Kg
Intravenous
Fluoroscent measurement
Significant amount of drugsa delivered in brain tissue
Peptide can deliver drugs into brain tissue
NA
NA
Doxorubicin+paclitaxel in 5mg/Kg combination
Brain glioma therapy
NA
NA
NA
27143884
b3pdb_0233
Protamine
VSRRRRRRGGRRRR
ValSerArgArgArgArgArgArgGlyGlyArgArgArgArg
NA
NA
NA
13
Linear
Cationic
Derived from protamine
NA
NA
NA
NA
NA
BALB/c mice
10 microliter per nostril
Intranasal
In vivo imaging
Peptide + BSA combination deleiveerd in brain olfactory bulb and littlebit in cerebral
peptide can deliver drug into brain tissue
NA
NA
Peptide+BSA
NA
NA
NA
NA
27471676
IIITD/CB
Raghava's Group
IMTECH
CellPPDMOD
